Academic Catalog


Course Code: 2380713
METU Credit (Theoretical-Laboratory hours/week): 3(3-0)
ECTS Credit: 8.0
Department: Biology
Language of Instruction: English
Level of Study: Graduate
Course Coordinator:
Offered Semester: Fall Semesters.

Course Content

Mechanism of oxygen activation in biological systems. Fundamental concepts on oxidases and oxygenases. Mechanism of action of dioxygenases, and monooxygenases. Special emphasis will be given on human enzymes including flavin containing monooxygenases, cytochrome P450- and cytochrome b5-dependent monooxygenases and nitric oxide synthase. Their importance in health and disease. Their structure, active sites, endogenous and exogenous substrates, structure-activity relationships, membrane topology, isomeric forms, molecular biology, gene structures and control mechanisms. Functions in human biochemistry including cholesterol, steroid hormone and vitamin synthesis and degradation, in drug metabolism and chemical carcinogenesis. The course includes lectures and discussions of recent journal articles.